Researchers from Anicom Specialty Medical Institute Inc., the National Institute of Genetics, and Kazusa DNA Research Institute have achieved a groundbreaking milestone by decoding the genome of American Shorthair cats. Published in a study last October, the genetic data revealed a total of 21,272 genes, surpassing the previously decoded Abyssinian cat genome by 1,685 genes.
This achievement sets a new Guinness World Record for the most comprehensive cat genome sequence and opens doors to innovative research in veterinary genetics and regenerative medicine. Using this detailed genetic information, the team, which also includes researchers from Osaka Metropolitan University and Tokiwa-Bio Inc., has produced high-quality induced pluripotent stem (iPS) cells from cats. These iPS cells are expected to significantly advance the study of genetic diseases and their treatments, as well as research into regenerative medicine.
In a related development, Shingo Hatoya, a professor at Osaka Metropolitan University, led efforts to collect sperm and eggs from cats undergoing contraception procedures. These reproductive cells were used to create fertilized eggs in vitro, leading to the production of embryonic stem cells (ES cells). These ES cells will serve as a standard for evaluating the quality of iPS cells, such as those created from skin cells, and could have future applications in preserving endangered cat species or advancing reproductive technologies for felines.
This breakthrough in feline genomics not only strengthens our understanding of cat biology but also holds potential for future medical advances, including improved treatments for genetic disorders and conservation of rare and endangered cat breeds.
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